Evaluation of Liver Function and Coagulation Profiles in Patients with Hepatitis B and C in Peshawar

Liver Function and Coagulation Profiles in Patients

Abstract

Background: Chronic liver disease is largely caused by Hepatitis B and C which is extremely rampant in Pakistan. Liver and coagulation profile assessment of Peshawar patients is relevant to detect the severity of the disease at an earlier stage and manage the disease better. The of study was to compare hepatitis B and hepatitis C patients with the aim of evaluating the difference in hepatic injury and liver functioning through the comparison of liver enzyme levels and coagulation parameters.

Material and Method: This case-control study was conducted at Al-Khidmat Hospital and Abasyn University Peshawar to assess liver and coagulation profiles in 100 participants, including 50 confirmed hepatitis B or C patients and 50 healthy controls.

Result: Among the 50 patients, 56% were HBV-positive and 44% HCV-positive, with a male predominance (58%). Abnormal elevations in ALT, ALP, and bilirubin were observed in a majority of infected individuals. Specifically, 60.7% of HBV-infected males and 50% of HCV-infected males exhibited elevated ALT levels, indicating liver inflammation. Also HBV and HCV had significantly increased levels of bilirubin and ALP and this indicated that there was hepatocellular injury and possible cholestasis or bone involvement. There was also presence of prolonged PT and APTT values in both male and female patients which showed evidence of liver synthetic impairment and high chances of bleeding. An example is the fact that 50% of HCV-positive males and 66% of HBV-positive males had high values of PT and that the same happened with APTT in the two groups.

Conclusion: The results emphasize the necessity to conduct regular screening through biochemical and hematological methods, particularly among the high-risk groups to avert the development of cirrhosis or Hepatocellular Carcinoma due to Hepatitis B and Hepatitis C.